COURSE INFORMATION
Immunology and Infectious Diseases

ID201 Malaria and Human Affairs
Spring
Department of Immunology and Infectious Diseases
Dr. A. Spielman, Dr. A. Teklehaimanot
2.5 credits
Lectures, seminars. One 2.5-hour session each week.

This course is designed to bring a multidisciplinary approach to a major public health problem in international health. Within the context of the biology and epidemiology of malaria, students are introduced to strategies for vector control, diagnosis, chemotherapy, and vaccines from the point of view of social, political, and economic policy. Impacts of programs are evaluated from an international and local perspective, using techniques from both the social and biomedical sciences.
Course Note: Signature of instructor required.

ID229 Epi of Infectious Diseases of Pub Hlth Import in Dev'g Countries
Fall 2
Department of Population and International Health and the Department of Immunology and Infectious Diseases
Dr. R. Cash
3.0 credits
Lectures, case studies. Three 2-hour sessions each week.

This course thoroughly reviews the epidemiology of infectious diseases of public health importance in developing countries. Emphasizes epidemiologic patterns of bacterial and viral diseases as they relate to different geographic and socioeconomic environments. Stresses methods of disease surveillance, especially with regard to prevention and control.
Course Activities: Case studies are extensively used with student teams proposing solutions to the problems.
Course Note: Ordinal grading option only.

ID267 Infectious Disease Epidemiology Seminar I
Fall
Department of Epidemiology and Department of Immunology and Infectious Disease
Dr. M. Lipsitch, Dr. M. Murray
2.5 credits
Seminars. One 2-hour seminar each week.

Seminars consist of presentations of student and faculty research in progress and discussion of recent publications in the field of infectious disease epidemiology. The emphasis is on conceptual issues related to the epidemiology of infectious diseases.
Course Activities: Individual student papers and presentations, student and faculty critiques.
Course Note: Must be taken for credit by students in the Program on the Epidemiology of Infectious Disease. Signature of instructor required. This course in intended for doctoral students currently involved in thesis work and for others with active research projects.

IMI201 Ecol, Epi, and Cntl of Impor Parasitic Diseases of Devel Areas
Fall 1
Dr. A. Sultan
3 credits
Lectures, seminars. Three 2-hour sessions each week.

Provides an introduction to ecological and epidemiological concepts basic to the control of infectious agents. Considers important parasitic diseases of particular significance in the developing areas of the world. Epidemiological principles of vector-associated diseases are elucidated through study of entities such as malaria and schistosomiasis.
Course Note: Background in biology required; knowledge of pathogenesis of infectious diseases desirable; signature of instructor required.

IMI202 Tuberculosis: the Host, the Organism, and the Global Threat
Spring 1
Dr. E. Nardell, Dr. E. Rubin
2.5 credits
Lectures. Two 2 -hour sessions each week.

This is a comprehensive survey course on tuberculosis featuring lectures by some of the leading authorities in the field. The first half of the course focuses on population issues (TB epidemiology in the US and the world), transmission, modeling, and programmatic issues (the essentials of good TB control both here and in high burden countries). The second month deals more with the biomedical aspects of TB, immunology, genetics, diagnosis, decision analysis, and treatment, again, both here and abroad. There is a field trip to the Massachusetts State Laboratory. Because of involvement of several of the faculty, special attention is paid to the global problem of multidrug resistant TB, and the work of Partners in
Health, an NGO associated with the medical school. During the second month, medical students join the SPH students for an elective course involving patient interviews at the state TB hospital. They present these cases and related topics in class during the second month. SPH students are evaluated on the basis of class participation and one or more presentations on relevant TB topics of interest. The course ends on or near World TB Day, with optional TB-related activities in the Boston area.
Course Note: This course is intended for students interested in any aspect of tuberculosis, biological, programmatic, international health, and epidemiologic. Some knowledge of immunology and molecular biology is desirable, but not required.

IMI204 Survey of Immunology
Spring 1
Dr. M. Grusby
1.25 credits
Lectures. One 1.5-hour session each week and one 1-hour DMS Weekly Immunology Seminar Series.

Introductory course aimed toward students who may not have a background in the biological sciences and/or immunology. Examines the anatomy and physiology of the immune system, and regulation of the immune response.

IMI206 Principles of Public Health Entomology
Spring 2
Dr. A. Spielman
2.5 credits
Lectures, seminars, field trips, laboratories. One 3-hour session each week.

The manner in which arthropods transmit disease and the principles of vector control are discussed from ecological, physiological, and genetic points of view. Class and laboratory sessions introduce concepts and techniques currently employed against vector-borne disease. Weekend field trips provide an opportunity for students to apply skills acquired in the classroom.
Course Note: IMI201 or signature of instructor required.

IMI208 Immunology of Infectious Diseases
Spring
Cross-listed at FAS as BPH-216 and at HMS as BPH-724.0
Dr. D. Harn, Department Members, Guest Lecturers
5 credits
To be given 2002-2003; offered alternate years.
Lectures, discussions. One 3-hour session each week.

Covers in detail the interactions of pathogens with the host immune system, including innate and protective responses and those immune responses that are deleterious. Lecture topics include: overview of immune responses; response of mucosal-secretory immune system to pathogens; innate immunity "the collectins", innate immunity "Th2 PAMPs"; pathogen regulatation of host immune responses; pathogen evasion of immune effector mechanisms; polarization of CD4+ T helper cell subsets and relationship to disease
outcome; resistance to HIV; HIV and co-infection with other pathogens; mechanisms of immunopathogenesis; and development of vaccines. Pathogens covered in detail include: HIV, cholera, TB, staph/strep, toxoplasma, intestinal protozoa, malaria, helminths.
Course Activities: Each lecture requires reading several relevant papers and completion of a problem set.
Course Note: Course in immunology required; enrollment limited to 35 students; signature of instructor required.

IMI216 Cellular and Molecular Biology of Parasites
Spring
Cross-listed at FAS as BPH-212 and at GSAS as IMM 214a and IMM214b and at HMS as BPH-721.0
Dr. B. Burleigh, Dr. A. Sultan, Department Members, Guest Lecturers
5 credits
Not to be given 2002-2003; offered alternate years.
Lectures, discussions. One 3-hour session each week.

This course covers aspects of biochemistry, cell and molecular biology of protozoa parasites of humans including: malaria, toxoplasma, leishmania, trypanosomes, amoebea and giardia. Will include in-depth discussions on comparative mechanisms of pathogenesis; unique parasite biochemistry and organelles; strategies/ molecular basis for host immune invasion; bioinformatics approaches to molecular pathogenesis.
Course Note: Suitable courses in biochemistry and genetics of microbiology required; enrollment limited to 35 students; signature of instructor required.

IMI222 The AIDS Epidemic: Status, Dynamics, Prospects, Conflicts
Fall 1
Dr. P. Kanki, Dr. M. Essex, Guest Lecturers
1.25 credits
To be given 2002-2003; offered alternate years.
Lectures. One 2-hour session each week.

Deals with a broad range of topics relating to the public health implications of the AIDS epidemic, including the virology, therapy, vaccines, and etiologic hypotheses concerning the origins of the virus. Topics for discussion and review include the dynamics of the epidemic, public policy issues relevant to measures to reduce the spread of infection, economic implications, and social support needs of affected persons.
Course Note: Knowledge of virology or clinical medicine helpful; minimum enrollment of 8 students required; enrollment limited to 30 students; signature of instructor required.

IMI225 Design & Development of a Vaccine
Spring
Dr. T.H. Lee, Dr. D Harn, Dr. M. Essex
2.5 credits
Not to be given 2002-2003; offered alternate years.
Lectures, case studies. One 2-hour session each week.

Covers such topics as methodology for new vaccine development, including development of vaccines for specific purposes; manufacturing and quality control; techniques to ensure appropriate use of vaccines; liability issues; cost-effectiveness analysis; decision analysis for future research, development, and distribution of vaccines; and epidemiology of vaccine preventable illness.
Course Note: Minimum enrollment of 12 students required.

IMI300 Independent Study/ Tutorial
Fall 1
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
Fall
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
Fall 2
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
Spring 1
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
Spring
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
Spring 2
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI300 Independent Study/ Tutorial
WinterSession
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of regular courses.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/ fail only; signature of instructor required.

IMI350 Research
Fall 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

IMI350 Research
Fall
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI350 Research
Fall 2
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI350 Research
Spring 1
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI350 Research
Spring
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI350 Research
Spring 2
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI350 Research
WinterSession
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
Fall 1
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

IMI400 Non-Resident Research
Fall
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
Fall 2
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
Spring 1
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
Spring
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
Spring 2
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

IMI400 Non-Resident Research
WinterSession
Department Members
Time and credit to be arranged.

For doctoral students who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied reserach in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/ fail only; signature of instructor required.

MCH306 Clinical Effectiveness Seminar
Fall/Spring
Dr. D. Goldmann, Dr. J. Perrin, Dr. J. Finkelstein, Dr. S. Muret-Wagstaff, Dr. T. Lieu
1.25 credits
Seminar. One 1.5-hour session each week.

This series of weekly seminars covers a broad spectrum of topics with content or methodologic relevance to research in child health services. The seminar series is coordinated by the Clinical Effectiveness Program at Children's Hospital together with The Division of General Pediatrics at Massachusetts General Hospital and The Department of Ambulatory Care and Prevention, Harvard Medical School. Speakers include faculty in and around the Harvard Medical Area as well as visiting speakers.
Course Note: Pass/Fail option only; signature of instructor required.

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