COURSE INFORMATION
Environmental Health

CCE 280cd. Biomarkers in Cancer Research (Department of Cancer Cell Biology and the Department of Environmental Health)
Dr. K. Kelsey
2.5 credits
Lectures, seminars. One 2-hour session each week.

This course covers the use of biomarkers as measures of exposure, absorbed dose, biological effect and health outcome in pre-neoplastic and neoplastic disease states.
Course Activities: Lectures and seminars relating to the use of biomarkers in epidemiologic studies.
Course Note: Introductory biostatistics and epidemiology required; toxicology and environmental epidemiology are suggested; minimum enrollment of 10 students required; enrollment limited to 25 students; signature of instructor required.

DBE 208cd. Pathophysiology of Human Disease (Division of Biological Sciences and the Department of Environmental Health)(Cross-listed at FAS as BPH-210 and at HMS as BPH-729.0)
Dr. L. Kobzik
5 credits
Lectures, seminars. Two 2-hour sessions each week.

Surveys major human disease problems in the cardiovascular, respiratory, hematopoietic, reproductive and gastrointestinal systems. Emphasis on understanding the pathophysiologic basis of common disease manifestations and the pathogenesis of the disease process. Relevant public health perspectives on the epidemiology or control of diseases are also integrated.
Course Note: College level physiology, EH 205ab, or equivalent required.

EEB 271c. Advanced Regression Techniques for Environmental Epidemiology (Departments of Environmental Health, Epidemiology and Biostatistics)
Dr. J. Schwartz, Dr. W. Huang
2.5 credits
Lectures and seminars. Two 2-hour sessions each week.

The course will cover nonlinear exposure-response relationships and repeated measure designs, including non-parametric and semi-parametric smoothing techniques, generalized additive models, robust regression and time series models. In addition to the theoretical material, students will apply these techniques using S-plus and SAS to actual datasets including modeling the effects of environmental exposures on health outcomes. These techniques also are widely applicable to problems in infectious disease, psychiatric, nutritional, occupational, and cancer epidemiology.
Course Activities: Lectures and structured workshops in the instructional computer facility.
Course Note: EPI 200a, EPI 200s, EPI 201a or EPI 208st, and BIO 233cd or BIO 211cd required; EPI 202b and EPI 204d are strongly recommended; minimum enrollment of 3 students required and limited to 15 students; signature of instructor required; lab or section time to be announced at first meeting.

EH 201b. Introduction to Environmental Health
Dr. J. Brain, Dr. R. Hauser, Department Members
2.5 credits
Lectures, case studies. Two 2-hour sessions each week.

This course offers a general introduction to the health problems stemming from contamination of air, water, food, the work place, and other special environments. Policy required for regulation and alternative strategies for prevention and control will be discussed. Links between environment and infectious disease will also be examined. This course is designed for the environmental non-specialist and meets the environmental health requirement for all professional master's degree programs.

EH 202d. Principles of Environmental Health
Dr. M. Perry (P), Dr. R. Monson (S)
2.5 credits
Lectures, case studies. Two 2-hour sessions each week.

This course will focus on the qualitative and quantitative aspects of the assessment of risk to health from environmental exposures; the use of such data in policy development and environmental management; and alternative legal strategies available to redress environmental injury and to control environmental degradation. The course meets the requirement for all professional master's degree programs.

EH 205ab. Human Physiology (Cross-listed at FAS as BPH-208 and at HMS as BPH-728.0)
Dr. N. Long Sieber, Dr. S. Shore
5 credits
Lectures, laboratories. Two 2-hour sessions each week, including 2 laboratory meetings during the semester.

As an introduction to the principles governing function in the human body, this course is designed to provide a framework in physiology for future public health researchers and professionals who have not taken college level physiology courses. Emphasis is placed on the concept of homeostasis and on integrative aspects of physiology. Examples of pathophysiology and environmental physiology will highlight these processes.
Course Activities: Problem sets, exams, laboratories.
Course Note: College-level introductory biology or permission of instructor required.

EH 223ab. Advanced Respiratory Physiology (Cross-listed at FAS as BPH-206)
Dr. J. Butler
5 credits
Lectures, seminars. Two 1.5-hour sessions each week.

Covers a broad range of topics in respiratory physiology including: lung structure, volume and flow mechanics, surfactant function, gas exchange, lung and chest wall interaction. Special topics may include pulmonary circulation, lung endocrine functions, airway physiology and pharmacology. Reviews classic concepts and presents some recent advances.
Course Activities: Student presentations.
Course Note: College-level physiology and EH 205ab or equivalent or signature of instructor indicating suitable background required.

EH 225cd. Advanced Topics in Physiology (Cross-listed at FAS as BPH-207 and at HMS as BPH-727.0)
Dr. J. Fredberg
5 credits
Lectures, supervised independent study. Two 1.5-hour sessions each week.

This course provides opportunities for students interested in the respiratory system to focus on special topics in lung biology. This year's emphasis will be on the fundamental physical basis and quantitative description of chemical, electrical and mechanical signaling within the cell. Specific topics covered will include passive diffusion, facilitated diffusion, solvent and solvent transport, channels, action potentials, membrane transport, receptor-ligand binding.
Course Activities: Students will explore one particular aspect and write a major research paper.

EH 231cd. Occupational Health Policy and Administration
Dr. C. Langer (P), Dr. D. Christiani (S)
2.5 credits
Lectures, seminars, case studies. One 2-hour session each week.

Examines the legal, economic, and political foundations of occupational health activities in the United States. Discusses the roles of government, unions, corporations, and research organizations. Helps students acquire an understanding of management functions in corporations.
Course Activities: Students develop the necessary knowledge and skills in the above areas to apply medical, industrial hygiene, and statistical skills to achieve a healthful workplace.

EH 232cd. Introduction to Occupational and Environmental Medicine
Dr. H. Hu, Dr. D. Christiani
2.5 credits
Lectures. One 2-hour session each week.

Reviews the diagnosis and management of illnesses following exposure to specific workplace substances and community hazards, such as asbestos, lead, organic solvents, and vibration. Considers methods of diagnosis of early organ system effects of chemicals and techniques for assessing disability.
Course Activities: Written and oral group projects.
Course Note: Basic course in toxicology recommended.

EH 235cd. Epidemiologic Basis of Occupational Health Standards
Dr. Eisen, Dr. D. Wegman
5 credits
Seminars, case studies. One 3-hour session each week.

Provides students with the opportunity to review the scientific basis for the association of selected occupational exposures and disease. Special emphasis is placed on the evaluation of the epidemiologic literature, occupational cancer, respiratory disease, and other kinds of occupational morbidity. Attention is directed to the interface of science and regulatory policy and the role of risk analysis in setting health standards.
Course Activities: Discussions based on the process leading to setting of standards.
Course Note: EPI 200a, EPI208st and BIO201ab and ID263cd required; enrollment limited to 20 students; signature of instructor required.

EH 241cd. Occupational Safety and Injury Prevention
Dr. J. Dennerlein, Dr. R. Youngstrom, Dr. R. Spielvogel
2.5 credits
Lectures, seminars. One 2-hour session each week.

This course in occupational safety works towards the prevention of work-related injury and illnesses through proactive management and control of workplace hazards. The primary objectives of the course are to: (1) identify fundamental workplace hazards, (2) develop a basis of basic government and voluntary regulations, (3) understand issues pertaining to specific and different industries, and (4) understand various safety management programs.
Course Activities: Lectures and group discussions, and a term project developing a employee-training program for injury prevention.

EH 243ab. Ergonomics and Human Factors
Dr. J. Dennerlein, Mr. T. Courtney, Dr. R. Herrick, Mr. R. Ciriello
2.5 credits
Lectures, seminars. One 2-hour session each week.

Emphasizes the design of the job "to fit the worker" in terms of both productivity and the prevention of injuries. Specific problems are investigated which result from the nature of the job itself, e.g., musculoskeletal disorders including low back pain and repetitive stress injuries of the upper extremity and human error. Fundamental ergonomic topics, such as human physiology, occupational biomechanics, epidemiology, and work place design, are considered in the development of good job design principles.
Course Activities: Lectures and group discussions, and a term project analyzing a real world job.

EH 250cd. Protecting Workers and Communities from Hazardous Substances
Dr. S. Rudnick, Mr. R. Spielvogel, Mr. K. Martin
2.5 credits
Lectures, laboratory sessions, field trip. One 2-hour session each week.

This course covers the recognition, evaluation, and control of workers and community exposure to hazardous substances. Particular emphasis is placed on remediation of hazardous waste sites, emergency response activities and related operations.
Course Activities: Written reports, class discussions and "hands-on" activities. Forty-hour Hazardous Waste Operations and Emergency Response certification may be awarded depending upon student's curriculum.

[EH 253cd.] Ventilation and Indoor Air Quality
Dr. S. Rudnick, Dr. J. Spengler, Mr. L. DiBerardinis
5 credits
Not to be given 2001-2002; offered alternate years.
Lectures, laboratory sessions, case studies and field trip. Two 2-hour sessions each week.

This course covers: systems used for heating, ventilation, and air conditioning of buildings and for ventilation to protect industrial workers; indoor air quality assessment and control including indoor contaminants, their sources, and their health effects.
Course Activities: Written reports, homework assignments, class projects, class discussions and student presentations.

EH 254cd. Evaluation and Control of Noise and Vibration
Dr. S. Rudnick
2.5 credits
To be given 2001-2002; offered alternate years.
Lectures, laboratory sessions, field trips. One 2-hour session each week.

This course covers the fundamental principles, evaluation, and control of noise and vibration with an emphasis on protecting workers.
Course Activities: Class discussion, homework assignments, written reports and class project.

EH 256cd. Introduction to Aerobiology
Dr. H. Burge, Dr. D. Milton, Mr. M. Muilenberg, Ms. C. Rogers
2.5 credits
Lectures, seminars. One 2-hour session each week.

This course emphasizes the pathways from reservoirs for biological-source disease agents to the ultimate response. Characteristics of the organism and their associated disease agents, biological and physical factors affecting aerosol formation, dispersion and decay, exposure factors, dose response data, and mechanisms of the disease processes are included, as are approaches for investigation, research design and risk assessment.
Course Activities: Lectures, discussions, research papers.

[EH 257cd.] Water Pollution
Dr. T. Ford, Dr. J. Shine
5 credits
Not to be given 2001-2002; offered alternate years.
Lectures. Two 2-hour sessions each week.

This course is designed to teach an understanding of the basic principles of water pollution and water pollution issues on local, regional and global scales. The course will begin with a discussion of the basic chemical, physical and biological properties of water and water contaminants, including hydrological considerations. Subsequent lectures will cover specific chemical and biological contaminants in ground, surface, brackish and marine waters; sources, fate, transport, and transformation of contaminants; monitoring techniques, water source protection and resource management; water and wastewater treatment; transmission of waterborne disease; toxicological concerns of chemicals in water, including disinfection byproducts; wetland ecology; remediation approaches; and interactions with the air and land environments. Invited lectures will cover issues such as harmful algal blooms, groundwater modeling, coastal zone management, and regulatory approaches for aquatic ecosystem protection. Course work will be complemented with exposure to research within the program on water and health.
Course Activities: Class discussions, homework assignments, and project.

EH 262ab. Introduction to the Work Environment
Dr. R. Herrick, Dr. J. Stewart
2.5 credits
Lectures, case studies. One 2-hour session each week.

The course comprises introductory lectures and discussions on key aspects of industrial hygiene and occupational health covering recognition, evaluation and control of health hazards at work. Consideration is given to chemical, physical and biological hazards, and the criteria for each. One or more visits are made to workplaces.
Course Activities: Written projects, class discussions, laboratories.
Course Note: While intended primarily for students planning a career in that field, this course provides background to the subject for students studying environmental issues and is strongly recommended for students intending to take ID 263cd.

EH 263cd. Analytical Methodology and Exposure Assessment
Dr. J. Shine, Dr. H. Suh
5 credits
Lectures, field work. Two 2-hour sessions each week.

This course will examine methodological issues associated with the design and execution of studies designed to measure environmental exposure to chemical and biological contaminants. The first half of the course will be lecture based, and will address topics such as: study design issues, implementation of quality control/ quality assurance programs, data analysis, protocols for sampling air, water, sediments, and soil for contaminants of concern, and analytical techniques used to measure chemical and biological constituents in the laboratory. During the second half of the semester, groups of students will design and execute their own field investigation using these techniques. The design and results of these projects are presented in class.
Course Activities: Lectures, written reports, class presentations, field work and final paper.
Course Note: Signature of instructor required for students not in the Environmental Science and Engineering Program.

EH 264cd. Water Systems Management
Dr. J. Harrington
2.5 credits
Lectures, seminars, case studies. One 2-hour session each week.

Provides students with an understanding of water engineering principles, emphasizing design and treatment of water supply systems in developing and developed countries.
Course Activities: Oral and written projects, class discussions, two field trips.

[EH 266cd.] Land Environment and Waste Management
Dr. M. First
2.5 credits
Not to be given 2001-2002; offered alternate years.
Lectures, readings, field trips. One 2-hour session each week.

An introduction to the nature, sources, and amounts of municipal, industrial, and hazardous wastes; the laws governing their storage, environmental control, transport, and disposal; municipal, industrial and hazardous waste management; waste minimization, elimination, and recycling; intermedia transfers, ground to water and ground to air.
Course Activities: Written and oral projects, class discussion, term paper, field trips to operating waste management, recycling and disposal facilities.
Course Note: Minimum enrollment of 9 students required.

EH 267cd. Industrial Hygiene/Ergonomics Internship and Environmental Sciences Research Seminar
Dr. R. Herrick, Dr. P. Koutrakis
2.5 credits
Seminars, case studies. One 2-hour session each week.

Material for this course is required for Industrial Hygiene concentrators doing the Internship Program and for Environmental Science and Engineering Program students doing research. The objective of the course is to refine communication skills. Students are required to prepare their own report, peer-review others and present the results.
Course Activities: Students present seminars on their recent internship or research projects.
Course Note: EH 273ab Industrial Hygiene Internship or EH 300 level research course is required; ordinal credit only.

EH 269cd. Exposure Assessment for Environmental and Occupational Epidemiology
Dr. T. Smith, Dr. H. Suh
2.5 credits
To be given 2001-2002; offered alternate years.
Lectures, readings, case studies. One 2-hour session each week.

Reviews the methods used to characterize environmental and occupational exposures. Presents approaches for biologically based exposure assessment matched to epidemiologic designs. Emphasizes evaluation of scientific literature.
Course Activities: Students will critique five case study papers and develop a plan for an exposure assessment on a topic of their choice. Instructors will provide feedback.
Course Note: Course recommended for doctoral and post-doctoral students in epidemiology, environmental science and engineering, and environmental biostatistics.

EH 270cd. Strategies for Environmental Management
Dr. R. Pojasek, Dr. J. Spengler
5 credits
Lectures, internet learning, case studies. Two 2-hour sessions each week.

Students will learn the skill of using problem solving tools for dealing with the environment, health and safety problems and managing the associated environmental risks. A number of tools are presented within a systems approach. These tools are widely used by industries and governmental organizations throughout the world. The student should be prepared to use these skills in team environments once they graduate from Harvard. Means of measuring progress and managing programs using the systems approach will be presented and discussed.
Course Activities: A semester long project will be completed by small groups on an actual project on a Harvard campus or a local institution. This will reinforce the skills gained in class. A second paper will be assigned to develop and used a problem-solving tool not covered in the course. There are no examinations in the course.

EH 273ab. Industrial Hygiene/Ergonomics Internship
Dr. R. Herrick
20 credits
Field work. Normal working hours of the company, in addition to time required for relevant reading.

The student works in an industrial or similar workplace under the direction of a qualified and experienced industrial hygienist (a mentor). Generally, the first half of the six-month period is devoted to learning evaluation techniques (e.g., personal air sampling, direct reading instrumentation, ventilation measurements), and the second half to studying some specific hazard or problem in depth, and preparing material for presentation in the succeeding course, EH 267cd.
Course Note: Completion of the first year of the two-year master's degree program in Industrial Hygiene required; ordinal grading option only; no auditors.

EH 278ab. Human Health and Global Environmental Change (Cross-listed at HMS as H0703.0)
Dr. H. Hu, Dr. P. Epstein, Dr. T. Ford, Dr. D. Goodenough, Dr. E. Chivian
5 credits or 2.5 credits (see below)
Lectures. One 4-hour session each week.

Human activity is changing the atmosphere and altering terrestrial and marine ecosystems on a global scale for the first time in history. Evidence is mounting that these changes may already be having serious effects on human health, and there is growing concern that in coming decades the effects could be catastrophic. This course will provide an overview of the basic physics, chemistry, and biology of global environmental change, and of the potential consequences of these changes for human health. It will cover global climate change, stratospheric ozone depletion, the effects of toxic substance pollution on global ecosystems, the degradation of terrestrial and marine environments, the loss of species and biodiversity, and the impact of these factors on human health. The role of rapidly growing human populations and of patterns of resource use and waste disposal in the genesis of environmental change will be examined. A multi-disciplinary faculty will provide an integrated assessment of these issues. The course will be open to all students at Harvard University, but preference will be given to students from HSPH, HMS, and KSG, as well as to Environmental Science Public Policy majors in the Faculty of Arts and Sciences.
Course Note: Enrollment limited to approximately 40 students from SPH, 75 students total. This course may be taken for either 5.0 credits or 2.5 credits. To register for 5.0 credits, select Section 1 (ordinal grading option) or Section 2 (pass/fail option only).

EH 279ab. The Radiation Environment: Its Identification, Evaluation and Control
Dr. J. Shapiro, Dr. A. Aro
2.5 credits
To be given 2001-2002; offered alternate years.
Lectures, seminars, case studies. One 2-hour session each week

Starting with the physics, mathematical analysis, and control of radiation fields, this course then treats in-depth topics selected according to the specific interests of the students, such as radiotherapy, medical imaging (x-rays, magnetic resonance, ultrasound), occupational and environmental radiation protection (radon, microwaves, ultra-violet radiation (UV), and electric and magnetic fields), and use of radiation as an analytical tool (bone-lead measurements, bone density, neutron activation analysis). The course has been developed with the needs of students enrolled in environmental science and engineering, occupational health and the MPH program in mind.
Course Activities: Students will conduct individual projects under faculty guidance compatible with their career interests and of public or occupational health concern. The end product of their research will be a position paper supporting a particular point of view and including risk-benefit and cost benefit arguments. In addition to library research and optional laboratory work, students will have the opportunity to conduct interviews with authorities in the field, and conduct workplace visits and field trips.
Course Note: Minimum enrollment of 5 students required; enrollment limited to 15 students; signature of instructor required.

EH 290a,b,c,d. Research in Physiology
Dr. J. Godleski, Dr. J. Fredberg
2.5 credits per period enrolled
Seminars, case studies. Two 2-hour sessions each week.

Focuses on the design, conduct, and analysis of research in physiology. Includes laboratory experience and the acquisition of original data and culminates in the presentation of a research project at a national meeting and in the preparation of a paper suitable for publication.
Course Note: No auditors.

EH 290a,b,c,d. Research in Physiology
Dr. J. Fredberg, Dr. J. Godleski, Dr. J. Brain
2.5 credits per period enrolled
Seminars, case studies. Two 2-hour sessions each week.

Focuses on the design, conduct, and analysis of research in physiology. Includes laboratory experience and the acquisition of original data and culminates in the presentation of a research project at a national meeting and in the preparation of a paper suitable for publication.
Course Note: No auditors.

EH 290a,b,c,d. Research in Physiology
Dr. J. Godleski, Dr. J. Brain, Dr. J. Fredburg
2.5 credits per period enrolled
Seminars, case studies. Two 2-hour sessions each week.

Focuses on the design, conduct, and analysis of research in physiology. Includes laboratory experience and the acquisition of original data and culminates in the presentation of a research project at a national meeting and in the preparation of a paper suitable for publication.
Course Note: No auditors.

EH 290a,b,c,d. Research in Physiology
Dr. J. Fredberg, Dr. J. Brain, Dr. J. Godleski
2.5 credits per period enrolled
Seminars, case studies. Two 2-hour sessions each week.

Focuses on the design, conduct, and analysis of research in physiology. Includes laboratory experience and the acquisition of original data and culminates in the presentation of a research project at a national meeting and in the preparation of a paper suitable for publication.
Course Note: No auditors.

EH 292cd. Air Pollution: Properties of Particles and Gases
Dr. S. Rudnick
2.5 credits
Lectures. One 2-hour session each week.

This course covers the fundamental properties, assessment, and control of airborne particles and gases relevant to public health.
Course Activities: Class discussions, homework assignments.

EH 295cd. Air Pollution: Atmospheric Processes, Modeling and Energy
Dr. J. Spengler, Dr. D. Bennett
2.5 credits
Lectures. One 2-hour session each week.

This course will address sources of air pollution, chemical transformations in the atmosphere, and physico-chemical properties and monitoring of air pollutants. Also, this course will discuss important topics of air pollution problems, such as atmosphere acidity, tropospheric and stratospheric ozone, hazardous air pollutants, and ambient particles.

EH 300a,b,c,d,s. Independent Study
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses. Opportunities are provided for independent studies in the fields of aerosol technology, air pollution control, environmental health management, environmental epidemiology, environmental microbiology, industrial hygiene and ventilation, nuclear medicine, occupational medicine, radiological health, respiratory biology, respiratory epidemiology, and solid waste management.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

EH 301a,b,c,d,s. Independent Study
Department Members
Time and credit to be arranged.

Course Note: Completed tutorial contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

EH 330e. Field Work
Department Members
Time and credit to be arranged.

Supervised site visits and field research projects are available in medical, industrial hygiene, and environmental health departments of industries and governmental agencies. Students in the various programs in occupational health may receive one credit for one week of fieldwork in the "e" period. Students participating in the industrial hygiene internship program receive 20 credits for fieldwork associated with their internship and should register for the internship through EH 273ab.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail option only; signature of instructor required.

EH 350a,b,c,d,s. Research
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking.
advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

EH 400a,b,c,d,s. Non-Resident Research
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking.
advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

[EH 506ab.] Advanced Seminar in Aerobiology
Dr. D. Milton, Dr. H. Burge
2.5 credits
Not to be offered 2001-2002; alternate year course.
Seminars. One 2-hour session each week.

This course is intended for students analyzing or ready to begin analysis of data for investigation of aerobiology, bioaerosol exposure assessment, or bioaerosol exposure-response relationships.
Course Activities: In the first hour of each class a student will present their work, research proposals, or critically review current literature with emphasis on implications for study design and data analysis. The second hour will be devoted to class discussion and feedback. Each presentation will be followed by submission of a brief written summary incorporating insights gained from class discussion. Evaluation will be based on presentations, written summaries, and class participation.

EHE 215cd. Environmental and Occupational Epidemiology (Department of Environmental Health and the Department of Epidemiology)
Dr. D. Dockery, Dr. R. Hauser
2.5 credits
Lectures, case studies. One 2-hour session each week.

This course has three objectives: to review methods used in evaluating the health effects of physical and chemical agents in the environment, to review available evidence on the health effects of such exposures, and to consider policy questions raised by the scientific evidence. Topics include lectures on methodology, seminars on the review and criticism of current literature, and presentations by outside experts on specific environmental and occupational health issues of current interest.
Course Note: EPI 200a, EPI 200s, EPI 201a or EPI 208st and BIO 200ab, BIO 201ab, BIO 206st, BIO 219ab or BIO 200s and BIO 200t required.

EHE 215t. Environmental and Occupational Epidemiology (Department of Environmental Health and the Department of Epidemiology)
Dr. R. Hauser, Dr. D. Dockery
2.5 credits
Lectures, case studies. Five 2-hour sessions each week.

This course has three objectives: to review methods used in evaluating the health effects of physical and chemical agents in the environment, to review available evidence on the health effects of such exposures, and to consider policy questions raised by the scientific evidence. Topics include lectures on methodology, seminars on the review and criticism of current literature, and presentations by outside experts on specific environmental and occupational health issues of current interest.
Course Note: EPI 200a, EPI 200s, EPI 201a or EPI 208st required; BIO 200ab, BIO 201ab, BIO 206st, BIO 219ab or BIO 200s and BIO 200t required (concurrent enrollment permitted).

EHE 268b. Respiratory Epidemiology (Department of Environmental Health and the Department of Epidemiology)
Dr. D. Dockery, Dr. C. Carmago
1.25 credits
Lectures, case studies. One 2-hour session each week.

Reviews the epidemiology of respiratory diseases, including chronic obstructive pulmonary disease, asthma, respiratory cancer, and infectious respiratory disease. Demographic distribution, time trends and risk factors of these diseases are discussed.
Course Note: EPI 200a, EPI 200s, EPI 201a or EPI 208st required.

[EHE 277b]. Modern Genetic Epidemiology and Gene Mapping (Department of Environmental Health and Department of Epidemiology)
Dr. X. Xu
2.5 credits
Not to be given 2001-2002; offered alternate years.
Lectures, seminars. One 2-hour session each week.

This multidisciplinary course is designed to provide a state-of-the-art guide to the emerging fields of modern genetic epidemiology and gene mapping in complex disorders. The completion of the Human Genome Project by 2003 will bring paradigmatic shifts of future human genetic epidemiologic studies. This course provides a comprehensive overview of the background of epidemiologic studies, epidemiologic methods and study designs, family and sib pair ascertainment, gene mapping technologies, computer software, data analysis, and interpretation. It will also explore a number of innovative new approaches for mapping genes of complex human diseases. In addition, the course will address the issues of genetic susceptibility, gene-gene interactions, and gene-environment interactions underlying common human diseases. This is a follow up course to BIO 227a and will emphasize the applications of the principles in genetic epidemiology and gene mapping. More theoretical methodology issues in human genetics will be covered in BIO 228cd.
Course Activities: Preparatory readings required for each lecture. Grades will be based on homework assignments, a quiz, and class participation.
Course Note: EPI 201a or EPI 201s and BIO 211cd, BIO 200ab, BIO 201ab or BIO 200s and BIO 200t required; enrollment limited to 20 students; signature of instructor required.

EHH 261ab. Properties of Environmental Contaminants (Departments of Environmental Health and Health Policy and Management)
Dr. D. Bennett, Dr. A. Eschenroeder, Dr. P.Koutrakis
5 credits
Lecture. Two 2-hour sessions each week.

This course is designed to provide the tools and foundation necessary to understand the physical and chemical properties of environmental contaminants, including their fate and transport in multiple environmental media. The course will include lectures on the laws of thermodynamics, the kinetic properties of gases, the structure and properties of gases, properties of liquids and solids, fugacity, chemical equilibrium, transport properties, kinetics, and particle behavior, among other topics.
Course Activities: Lectures, class discussions, homework assignments, mid-term and final exams.
Course Note: Calculus and chemistry required; course required for all Environmental Science and Engineering Program students.

EHH 500d. Risk Assessment (Department of Environmental Health and the Department of Health Policy and Management)
Dr. J. Levy, Dr. J. Evans
2.5 credits
Lectures. Two 2-hour sessions each week.

Introduces the framework of risk assessment, considers its relationship with cost-benefit, decision analysis and other tools for improving environmental decisions. The scientific foundations for risk assessment - epidemiology, toxicology, and exposure assessment are discussed. The mathematical sciences involved in developing models of dose-response, fate and transport, and the statistical aspects of parameter estimation and uncertainty analysis are introduced. Case studies are used to illustrate various issues in risk assessment and decision making.
Course Activities: Lectures, discussions, computer workshops, case studies.
Course Note: Course required for all Environmental Science and Engineering Program students; minimum enrollment of five students required; enrollment limited to 30 students.

EHH 501c. Regulatory Toxicology (Department of Environmental Health and the Department of Health Policy and Management)
Dr. G. Gray
2.5 credits
Lectures. Two 2-hour sessions each week.

Covers basic principles of toxicology and how animal and human studies are used to further the understanding of dose-response relationships. The toxicological evidence for regulating chemicals in the general environment, the workplace and food supply is covered. Quantitative pharmacokinetic and dose-response models used in risk assessment are presented.
Course Activities: Lectures, discussions, case studies.
Course Note: Calculus and chemistry or biology courses required; EH 205ab required; course required for all Environmental Science and Engineering Program students; signature of instructor required if student has not completed prerequisite.

[EHH 502d]. Environmental Pollution: Exposure Modeling (Department of Environmental Health and the Department of Health Policy and Management)
Dr. J. Evans, Dr. A. Eschenroeder
2.5 credits
Not to be given 2000-2001; offered alternate years.
Lectures. Two 2-hour sessions each week.

This course will introduce approaches for estimating human exposure to environmental pollution in situations where measurements are unavailable or uninformative. The course will focus on models of the fate and transport of pollutants in air, water and soil. It will consider the major routes of uptake: inhalation, ingestion and dermal uptake. Specific models discussed will vary from year to year, but typically include the Gaussian air pollution model, one-dimensional advection-dispersion models of groundwater, multicompartment models such as fugacity and pharmacokinetic models, and source-receptor models. Students learn to build exposure models using Lotus spreadsheets and learn to use several of the major models commonly used for the analysis of environmental exposures.
Course Activities: Written and oral projects, class discussions.

[EHH 503ab.] Environmental Science and Risk Management Practicum (Department of Environmental Health and the Department of Health Policy and Management)
Dr. J. Evans, Department Members
5 credits
Not to be given 2001-2002; offered alternate years.
Seminars. Two 2-hour sessions each week.

The practicum is designed to allow ESRM students to integrate what they have learned about risk and decision sciences and to apply this knowledge in the evaluation of a problem (of importance) in environmental management or policy. Each student must design and conduct an independent analysis of an environmental policy problem. Student projects must demonstrate analytical sophistication and critical interpretation of relevant science in support of decision making. Each student must prepare a written report and make an oral presentation of results to the ESRM faculty. The practicum is a requirement for and is restricted to all students in the ESRM masters and doctoral program.

EHH 505cd. Industrial Ecology and Life Cycle Assessment (Department of Environmental Health and the Department of Health Policy and Management)
Dr. G. Norris, Dr. J. Spengler
Cancelled for 2001-2002 academic year only.
2.5 credits
Lectures, seminars, case studies. One 2-hour session each week.

This course will investigate the rationale for, methods of, findings from, and research needs within the field of industrial ecology, with a particular focus on product-based analyses and environmental life cycle assessment. We know that processes within an industrialized economy are highly interconnected, so that activities associated with one industry or product can stimulate a whole chain of environmental impacts. The course will investigate if such interconnections can be meaningfully assessed in ways that provide useful information on how to support improved environmental decision making by private industry and policy makers. We will review recent and current applications in industry and government as well as active research in the US and internationally.
Course Activities: Discussions, computer workshops and a class project.

EPH 227d. Principles of Screening
Dr. G. Colditz, Dr. B. Rockhill
2.5 credits
Lectures, seminars, case studies. Two 2-hour sessions each week.

The aim of this course is to provide a basic understanding of the principles of disease screening. Particular emphasis is placed on screening from a public health perspective. The first part of the course will focus on the quantitative foundations underlying screening evaluation. We will review current approaches to screening for cancer, as well as applications in a number of other settings. Controversies and limitations of screening strategies will be discussed.
Course Activities: Class participation in seminars and formal debates, one problem set, and final 5-10 page paper.

HPE 284ab. Decision Theory (Department of Health Policy and Management and the Department of Environmental Health)
Dr. J. Hammitt
5 credits
Lectures. Two 2-hour sessions each week.

Introduces the standard model of decision-making under uncertainty, its conceptual foundations, challenges, alternatives, and methodological issues arising from the application of these techniques to health issues. Topics include von Neumann-Morgenstern and multi-attribute utility theory, Bayesian statistical decision theory, stochastic dominance, the value of information, judgment under uncertainty and alternative models of probability (Dempster-Shafer theory, generalized probability), and decision making (regret theory, prospect theory, generalized expected utility). Applications are to preferences for health and aggregation of preferences over time and across individuals.
Course Note: Prior course work in decision analysis required.

HPE 285d. Environmental Health Risk: Concept and Cases (Department of Health Policy and Management and the Department of Environmental Health)
Dr. K. Thompson
2.5 credits
Seminars. Two 2-hour sessions each week.

Challenges students to evaluate the risk analysis framework as an approach to managing environmental health and safety, and other hazards. Addresses contemporary issues in risk assessment, evaluation, management, and communications using a case-method approach.

ID 263cd. Practice of Occupational Health (Department of Environmental Health)
Dr. T. Smith, Dr. R. Herrick
5 credits
Lectures, case studies. Two 2-hour sessions each week.

Focuses on the assessment of workplace hazards, the physiology and biomechanical aspects of work, and a practical problem-solving approach to health problems in various work settings. Emphasizes the relationship between working conditions and health, with special reference to the recognition, measurement, and control of occupational hazards.
Course Activities: Oral and written projects, class discussions, walk-through field trips to local industries (field trips may take up to four hours).
Course Note: EH 262ab recommended; signature of instructor required; no auditors.

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