COURSE INFORMATION
Division of Biological Sciences

DBE 208cd. Pathophysiology of Human Disease (Division of Biological Sciences and the Department of Environmental Health)(Cross-listed at FAS as BPH-210 and at HMS as BPH-729.0)
Dr. L. Kobzik
5 credits
Lectures, seminars. Two 2-hour sessions each week.

Surveys major human disease problems in the cardiovascular, respiratory, hematopoietic, reproductive and gastrointestinal systems. Emphasis on understanding the pathophysiologic basis of common disease manifestations and the pathogenesis of the disease process. Relevant public health perspectives on the epidemiology or control of diseases are also integrated.
Course Note: College level physiology, EH 205ab, or equivalent required.

[DBN 209a]. Membrane Trafficking (Division of Biological Sciences and the Department of Nutrition)
Dr. M. Wessling-Resnick, Members of the Faculty
2.5 credits
Not to be given 2001-2002; offered alternate years.
Lectures, seminars, case studies. One 3-hour session each week.

Intercellular membrane traffic plays an essential role in nutrient uptake, entry of micro-organisms into cells, and receptor-down-regulation, thus defects in this process can create a profound pathophysiology. This course will provide a detailed molecular overview of the elements involved in membrane traffic, how these pathways are interconnected, and the regulatory mechanisms responsible for maintaining cellular integrity through membrane traffic. This course will emphasize the interdisciplinary interests in this area.
Course Note: This course will be offered as a DBS "short course" in the DMS catalog and will also be incorporated into the "short course" format under the Biological and Biomedical Sciences (BBS) program; ordinal grading option only.

DBN 211cd. Frontiers of Cardiovascular Biology (Division of Biological Sciences and the Department of Nutrition)
Dr. G. Reed, Dr. G. Huggins
2.5 credits
Lectures, seminars. One 3-hour session each week.

Current concepts of cardiovascular diesease with an emphasis on underlying cellular and molecular mechanisms. Topics include: heart and blood vessel development (with emphasis on the cardiomyopathies, congenital heart disease, and other causes of heart failure); interactions of the blood cells with the blood vessels (focusing on thrombosis and arteriosclerosis as causes of heart attacks and strokes). Whenever possible insights to the assessment of genetic risk on cardiovascular disease will be emphasized. Facult will provide a broad overview of the topic, a general discussion of the research approaches used and a discussion of important unaswered questions. The remainder of the seminar will focus on student-led discussions of relevant current (primary) literature.
Course Note: Pass/fail only based on course participation. Minimum enrollment of 6 students.

DBS 201b. Interface of Biology & Public Health: Core Knowledge for the 21st Century
Dr. D. Wirth, Department Members
2.5 credits
Lectures, seminars. Two 2-hour sessions each week.

This course is for all students who plan professional careers in public health. The course is designed to relate to specific public health problems and will focus on the underlying biological mechanisms relevant to major public health problems. Each week will focus on a fundamental aspect of modern biological sciences. Emphasis will be placed on concepts important for public health professionals and decision makers. The course will include lectures, discussion, readings and written exercises. No previous training in modern biological sciences is required.
Course Note: Minimum enrollment of 10 students. Enrollment limited to 40 students; pass/fail option allowed with permission of instructor; signature of instructor required.

DBS 205ab. Biological Sciences Seminars (Cross-listed at FAS as BPH-219)
Dr. M. Grusby, Dr. I. Ho
5 credits
Seminars. Two 1.5-hour sessions each week.

Faculty present seminars on their current research in the biological sciences and direct a student discussion of the logic and experimental design of this research. Topics include chemical and viral carcinogenesis, DNA damage and repair, immunology, molecular biology, metabolism, cardiovascular disease, parasitology, and how these areas apply to public health issues.
Course Note: Required for first-year students in the DBS/BPH program.

DBS 300ab,cd. Laboratory Rotations
Director, Department Members
Time and credit to be arranged.
Laboratories. 12-20 hours each week.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses. Offers hands-on experimental methods of research in the biological sciences. Students perform individualized and original laboratory work. Includes participation in seminars, journal clubs, and assigned readings.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

DBS 301a,b,c,d. Special Seminar
Department Members
Time and credit to be arranged.

Topics and meeting time to be determined.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

DBS 350a,b,c,d,s. Research
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department. Inquiries about specific research opportunities should be addressed to the chair of the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

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