COURSE INFORMATION
Cancer Cell Biology

CCB 210ab. Introduction to Cancer Biology (Cross-listed at FAS as BPH-205 and at HMS as BPH-726.0)
Dr. C. Maki
5 credits
Lectures. Two 2-hour sessions each week.

Emphasizes current experimental approaches to studying cancer biology and the process of carcinogenesis. Topics include the biology of cell modification and differentiation, the phenotype of the cancer cell, properties of human and animal cancers, the process of cell transformation, mutagenesis, carcinogen metabolism, and cancer epidemiology.
Course Note: College-level course in biology required; enrollment limited to 30 students; signature of instructor required. Ordinal grading only. No auditors.

[CCB 225cd.] Genetic Toxicology (Cross-listed at HMS as BPH-217)
Dr. L. Samson, Guest Lecturers
5 credits
Not to be given 2001-2002; offered alternate years.
Lectures. Two 2-hour sessions each week.

Explores the biological consequences of the interaction of DNA damaging agents with the genome. Topics include DNA structure, DNA repair; DNA damage-inducible processes, mutagenesis and mutational spectra, cell death by apoptosis, and genetic toxicity testing.
Course Activities: Participation in discussions, oral and written projects.
Course Note: Background courses in biochemistry, cell biology, and genetics required; signature of instructor required; enrollment limited to 20 students.

[CCB 250cd.] Cell Response to Mutagens and Carcinogens (Cross-listed at FAS as BPH-213 and at HMS as BP-723.0)
Dr. B. Demple
5 credits
Not to be given 2001-2002; offered alternate years.
Seminars. Two 2-hour sessions each week.

A seminar course based on emerging research on the molecular effects of mutagenic, carcinogenic, and cytoxic agents. Particular focus on the cellular mechanisms that preserve biological integrity (e.g., cell cycle checkpoints; DNA repair) or mediate cellular responses to stress (e.g., redox signal transduction; apoptosis pathways).
Course Activities: This seminar course involves analysis and critical discussion of research papers. Written assignments in developing relevant research projects (mini-grant proposals).
Course Note: Advanced/ graduate courses in biochemistry, cell biology or genetics required.

CCB 300a,b,c,d,s. Independent Study
Department Members
Time and credit to be arranged.

An opportunity for independent study is offered for interested and qualified students or small groups of students. Arrangements must be made with individual faculty members and are limited by the amount of faculty time available. These programs are open to all students who wish to go beyond the content of the regular courses. Opportunities are provided for independent studies in molecular, cellular, biochemical, and environmental toxicology, in cancer cell development, and in radiobiology.
Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

CCB 301a,b,c,d,s. Tutorial
Department Member
Time and credit to be arranged.

Course Note: Completed independent study contract is required at the time of registration; maximum of 5 credits per independent study topic; pass/fail only; signature of instructor required.

CCB 350a,b,c,d,s. Research
Department Members
Time and credit to be arranged.

For doctoral candidates who have passed their school-wide Oral Qualifying Examination and who are undertaking advanced work along the lines of fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of instructor required.

CCE 204ab. Principles of Toxicology (Cross-listed at FAS as BPH-215 and at HMS as BPH-713.0)(Department of Cancer Cell Biology and Department of Environmental Health)
Dr. D. Wolf, Dr. D. Milton
5 credits
Lectures. Two 2-hour sessions each week. One 2-hour discussion session each week.

Emphasizes mechanisms of injury and clinical consequences following exposures to environmental and occupational chemicals. Examines actions at the molecular, cellular, organ system, and organismal levels. Discusses methods for detecting, evaluating, analyzing, and combating toxic effects.
Course Activities: Written examinations.
Course Note: Organic chemistry and mammalian physiology or equivalents required. Required lab.

CCE 280cd. Biomarkers in Cancer Research (Department of Cancer Cell Biology and the Department of Environmental Health)
Dr. K. Kelsey
2.5 credits
Lectures, seminars. One 2-hour session each week.

This course covers the use of biomarkers as measures of exposure, absorbed dose, biological effect and health outcome in pre-neoplastic and neoplastic disease states.
Course Activities: Lectures and seminars relating to the use of biomarkers in epidemiologic studies.
Course Note: Introductory biostatistics and epidemiology required; toxicology and environmental epidemiology are suggested; minimum enrollment of 10 students required; enrollment limited to 25 students; signature of instructor required.

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