Cancer Cell Biology
CCB 210ab. Introduction to Cancer Biology (Cross-listed at FAS as
BPH-205 and at HMS as BPH-726.0)
Dr. C. Maki
Lectures. Two 2-hour sessions each week.
Emphasizes current experimental approaches to studying cancer biology and
the process of carcinogenesis. Topics include the biology of cell
modification and differentiation, the phenotype of the cancer cell,
properties of human and animal cancers, the process of cell
transformation, mutagenesis, carcinogen metabolism, and cancer
Course Note: College-level course in biology required; enrollment limited
to 30 students; signature of instructor required. Ordinal grading only.
[CCB 250cd.] Cell Response to Mutagens and Carcinogens (Cross-listed at
FAS as BPH-213 and at HMS as BP-723.0)
Dr. B. Demple
Not to be given 2001-2002; offered alternate years.
Seminars. Two 2-hour sessions each week.
A seminar course based on emerging research on the molecular effects of
mutagenic, carcinogenic, and cytoxic agents. Particular focus on the
cellular mechanisms that preserve biological integrity (e.g., cell cycle
checkpoints; DNA repair) or mediate cellular responses to stress (e.g.,
redox signal transduction; apoptosis pathways).
Course Activities: This seminar course involves analysis and critical
discussion of research papers. Written assignments in developing relevant
research projects (mini-grant proposals).
Course Note: Advanced/ graduate courses in biochemistry, cell biology or
CCB 300a,b,c,d,s. Independent Study
Time and credit to be arranged.
An opportunity for independent study is offered for interested and
qualified students or small groups of students. Arrangements must be made
with individual faculty members and are limited by the amount of faculty
time available. These programs are open to all students who wish to go
beyond the content of the regular courses. Opportunities are provided for
independent studies in molecular, cellular, biochemical, and
Course Note: Completed independent study contract is required at the time
of registration; maximum of 5 credits per independent study topic;
pass/fail only; signature of instructor required.
CCB301. a,b,c,d,s Tutorial
Course Note: Completed independent study
contract is required at the time of registration; maximum of 5 credits
per independent study topic; pass/fail only; signature of instructor
CCB 350a,b,c,d,s. Research
Time and credit to be arranged.
For doctoral candidates who have passed their school-wide Oral Qualifying
Examination and who are undertaking advanced work along the lines of
fundamental or applied research in the department.
Course Note: Pass/Fail only; maximum of 20 credits; signature of
CCE 204ab. Principles of Toxicology (Cross-listed at FAS as BPH-215 and
at HMS as BPH-713.0)(Department of Cancer Cell Biology and Department of
Dr. D. Wolf, Dr. D. Milton
Lectures. Two 2-hour sessions each week. One 2-hour discussion session
Emphasizes mechanisms of injury and clinical consequences following
exposures to environmental and occupational chemicals. Examines actions
at the molecular, cellular, organ system, and organismal levels.
Discusses methods for detecting, evaluating, analyzing, and combating
Course Activities: Written examinations.
Course Note: Organic chemistry and mammalian physiology or equivalents
required. Required lab.
CCE 280cd. Biomarkers in Cancer Research (Department of Cancer Cell
Biology and the Department of Environmental Health)
Dr. K. Kelsey
Lectures, seminars. One 2-hour session each week.
This course covers the use of biomarkers as measures of exposure,
absorbed dose, biological effect and health outcome in pre-neoplastic and
neoplastic disease states.
Course Activities: Lectures and seminars relating to the use of
biomarkers in epidemiologic studies.
Course Note: Introductory biostatistics and epidemiology required;
toxicology and environmental epidemiology are suggested; minimum
enrollment of 10 students required; enrollment limited to 25 students;
signature of instructor required.